British Dragon
British Dragon
Mesterolone 25 mg
Product Information Compound Details
Active Substance Mesterolone Oral DHT-Derived Androgen
25 mgStrength 25 mg/tablet
Package 50 Tablets 1,250 mg Total Labeled Content
Form Oral Tablets
Drug Class Androgen
Estimated Half-Life Approximately 12–13 Hours
Manufacturer British Dragon
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- Overview
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Product Overview
Mesterolone 25 mg by British Dragon
Mesterolone 25 mg is an oral androgenic tablet manufactured by British Dragon and dosed at 25 mg per tablet, supplied in packs of 50 tablets.
Mesterolone Oral
Mesterolone 25 mg contains mesterolone, a synthetic orally active androgen that is structurally related to dihydrotestosterone (DHT) . In clinical medicine, mesterolone is indicated for androgen replacement in male hypogonadism where androgen deficiency is confirmed by clinical and biochemical testing. It has also been used to treat male infertility associated with oligospermia, where it is thought to improve sperm count and quality by raising and normalizing fructose concentration in the ejaculate.
Mesterolone differs from many other oral androgens in that early studies suggested it did not usually suppress gonadotropins or endogenous testosterone production, although a later single-dose study suggests there may be a central suppression effect at doses of 75-100 mg daily. It is rapidly absorbed after oral ingestion, reaching peak serum levels at approximately 1.6 hours, with a terminal half-life of 12-13 hours. The drug is extensively bound to plasma proteins (98%), with 58% bound to sex hormone-binding globulin (SHBG) and 40% to albumin.
In non-medical bodybuilding contexts, mesterolone is commonly referenced as an ancillary compound rather than a primary anabolic agent. Its relatively weak anabolic activity and strong androgenic properties mean it is not used for significant muscle mass gains. Instead, it is typically referenced for its ability to bind to SHBG, which may increase the proportion of free, biologically active testosterone available to interact with target tissues. This mechanism is why mesterolone is sometimes discussed in non-medical contexts alongside other compounds. Such use falls outside approved indications.
Key Properties of Mesterolone 25 mg
- Orally active androgen structurally related to dihydrotestosterone (DHT)
- Clinically indicated for male hypogonadism and androgen deficiency
- High binding affinity for SHBG may increase free testosterone levels
- Rapid oral absorption with terminal half-life of 12-13 hours
- 50 tablet pack size supports research protocols
Product Profile
Mesterolone Profile
Mesterolone is a synthetic oral androgen with strong androgenic and relatively weak anabolic properties, primarily used clinically for androgen replacement therapy.
Oral Androgen (DHT Derivative)
Mesterolone is a derivative of dihydrotestosterone (DHT) with a 1-alpha methyl group that allows it to survive first-pass metabolism in the liver, enabling oral bioavailability. Unlike testosterone, mesterolone does not convert to estrogen, meaning it does not cause water retention or gynecomastia. This structural characteristic is why the compound is sometimes referenced in non-medical contexts where estrogenic side effects are a concern.
Mesterolone's mechanism of action involves dual activity. It acts as an agonist at the androgen receptor, and it exhibits a high binding affinity for sex hormone-binding globulin (SHBG). By binding to SHBG, mesterolone may displace testosterone from this binding protein, increasing the proportion of free, biologically active testosterone that can interact with target tissues. This mechanism is the basis for its discussion in non-medical bodybuilding contexts, where it is sometimes referenced alongside other compounds to potentially enhance the effects of co-administered androgens.
Clinical research has explored mesterolone in several contexts. A double-blind controlled study investigated its effects in depressed patients, based on computer EEG profiles predicting antidepressant properties of the synthetic androgen. Another study compared the antidepressant effects of mesterolone and amitriptyline in depressed men, finding the two drugs equally effective in reducing depressive symptoms, with mesterolone producing significantly fewer adverse side effects.
Clinical Status
Approved for Hypogonadism — Not for Performance Use
Mesterolone is approved for androgen replacement in male hypogonadism. Official product information explicitly states that androgens are not suitable for enhancing muscular development in healthy individuals or for increasing physical ability.
Mesterolone 25 mg vs Other British Dragon Preparations
British Dragon offers several oral compounds with distinct characteristics. Oxanabol contains oxandrolone, a milder oral with primarily anabolic activity. Stanabol 10 contains stanozolol, a non-17α-alkylated oral with lower liver toxicity. Methanabol contains methandienone, a more strongly anabolic oral.
Mesterolone's distinguishing characteristic is its strong androgenic and weak anabolic profile, combined with its high SHBG binding affinity. This makes it conceptually different from compounds used for muscle growth, and it is instead referenced for potential effects on free testosterone availability and androgenicity.
Dosage & Usage
Mesterolone 25 mg Dosage & Usage
The information below is provided for educational reference only. Mesterolone is a prescription androgen; medical use requires appropriate diagnosis, clinical supervision, and ongoing monitoring. Non-medical use falls outside approved indications.
Typical Dosage Ranges
In clinical practice, the recommended starting dose for adults is 3 to 4 tablets (75-100 mg) daily for several months, followed by maintenance therapy of 2-3 tablets (50-75 mg) daily. For specific indications such as decline in physical activity and mental agility in advanced age, an initial dose of 25 mg three times daily may be used until satisfactory response is achieved, followed by maintenance of 25 mg once or twice daily. In non-medical bodybuilding contexts, mesterolone is commonly referenced at lower doses, typically 25 to 50 mg daily, though such use falls outside approved indications.
| Use Case | Common Reference Range | Frequency |
|---|---|---|
| Clinical (initial therapy) | 75–100 mg | Daily, 3–4 tablets |
| Clinical (maintenance) | 50–75 mg | Daily, 2–3 tablets |
| Non-medical (reported) | 25–50 mg | Daily |
These non-medical ranges represent community-reported practices and are not derived from controlled clinical trials for performance enhancement. Mesterolone's clinical use in hypogonadism involves ongoing monitoring and dose adjustment based on response.
Stacking & Cycle Considerations
In non-medical bodybuilding contexts, mesterolone is sometimes referenced alongside aromatizing compounds such as Testabol Depot or Methanabol. The rationale discussed in these contexts is mesterolone's SHBG binding, which may increase free testosterone levels. It is also sometimes referenced during cutting phases for its androgenic effects, though its weak anabolic activity limits its utility for muscle preservation.
Because mesterolone does not aromatize, it is not associated with estrogenic side effects. However, it is not a substitute for aromatase inhibitors when managing estrogen from other compounds.
Managing Side Effects
Mesterolone is generally well tolerated in clinical use. The most common side effects reported in product information include frequent or persistent erections (priapism), which may require dose reduction or discontinuation to avoid penile injury. Other potential effects include increased libido and, in older men, precipitation of urinary obstruction.
Hormonal substances such as mesterolone have been rarely associated with benign and, in very rare cases, malignant liver tumours. If severe upper abdominal complaints, liver enlargement, or signs of intra-abdominal haemorrhage occur, the possibility of a liver tumour should be considered.
Important
Individual Response Varies
Mesterolone has approved dosing for specific medical indications. Any information about non-medical use is derived from user-reported practices and is not validated by controlled clinical research. This information does not constitute medical advice.
Safety & Information
Mesterolone Safety Information
Mesterolone is a prescription androgen with known risks that require clinical oversight. It is contraindicated in prostate carcinoma and previous or existing liver tumours.
Important Safety Information
Mesterolone is contraindicated in the presence of prostatic carcinoma, as androgens can stimulate the growth of an existing carcinoma. It is also contraindicated in previous or existing liver tumours, breast cancer, hypercalcaemia, and hypersensitivity to the active substance or excipients.
The diagnosis of hypogonadism in males requires full endocrinological assessment including clinical history, physical examination, and interpretation of serum testosterone, LH and FSH measurements. Prostate disease should be excluded prior to commencement, and regular examinations of the prostate should be carried out prophylactically.
Important
Non-Medical Use
Non-medical use of mesterolone falls outside approved indications. Official product information states that androgens are not suitable for enhancing muscular development in healthy individuals. Product purity does not establish that non-medical use is safe or appropriate.
Potential Adverse Effects
Frequent or persistent erections (priapism) may occur during treatment. If this happens, the dose should be discontinued to avoid injury to the penis. In older men, urinary obstruction may be precipitated. Increased libido may occur.
In rare cases, benign liver tumours and in even rarer cases malignant liver tumours leading to life-threatening intra-abdominal haemorrhage have been observed after the use of hormonal substances such as mesterolone. Severe upper abdominal complaints, liver enlargement, or signs of intra-abdominal haemorrhage should prompt consideration of liver tumour in the differential diagnosis.
Androgens may exacerbate conditions aggravated by fluid overload, such as cardiovascular disorders, renal impairment, hypertension, epilepsy, or migraine. Use in puberty may cause premature closure of the epiphyses and stop linear growth. Diabetes mellitus, androgen-sensitive polycythaemia, or sleep apnoea may be exacerbated.
Conditions Requiring Medical Evaluation
Mesterolone is not appropriate for everyone. Contraindications include prostatic carcinoma, previous or existing liver tumours, breast cancer, hypercalcaemia, and hypersensitivity to the active substance or excipients.
Prostate examination should be performed regularly during treatment to exclude prostatic carcinoma. Hepatic function monitoring is recommended in patients with hepatic impairment.
Monitoring During Therapy
Medically supervised mesterolone therapy may involve regular prostate examinations to exclude prostatic carcinoma, monitoring of hepatic function, and assessment of clinical response. Product information notes that androgens may influence laboratory test results, including thyroid hormone binding globulin levels.
Product Care
Storage & Handling
Store below 30°C in a cool, dry place, away from direct light and moisture. Keep out of reach and sight of children. Inspect tablets before use and do not use if they appear damaged or compromised.
Further Safety Information
Shipping & Authenticity
Shipping & Product Authenticity
Mesterolone 25 mg is supplied through the official British Dragon distribution chain and shipped in original manufacturer packaging with discreet, privacy-focused handling.
USA Domestic 3–5 business days
International 10–15 business days
Order Processing 24–48 business hours
Tracking Provided after dispatch
Direct Supply
Discreet Delivery & Original Packaging
The outer shipping package remains discreet, with privacy-focused handling and no unnecessary external product details. Products are supplied through the official British Dragon distribution chain.
What to Expect
- Orders are processed after payment confirmation
- USA Domestic shipping is typically faster when local stock is selected
- International orders include tracking, though update frequency may vary by destination
- Multiple warehouses may result in separate shipments when applicable
Authenticity Verification
To verify your Mesterolone 25 mg product, use the security code on the packaging and cross-check it on the British Dragon official site. Official British Dragon presentation and original packaging help reinforce product legitimacy and buyer confidence.
For complete delivery details, tracking policy, and reshipment terms, please see our Shipping Info page.
Storage
Mesterolone 25 mg Storage
Proper storage conditions help preserve tablet stability and overall product integrity throughout shelf life.
Recommended Conditions
Store below 30°C in a cool, dry place, away from direct light and moisture. Keep tablets in their original packaging until use to protect from humidity.
Inspect tablets before use and do not use if they appear discolored, cracked, or otherwise compromised. Keep out of reach and sight of children.
Quick Reference
Do & Don't
- Do store below 30°C
- Do keep in original packaging
- Do inspect before each use
- Don't expose to direct sunlight or moisture
- Don't store in bathroom or humid areas
- Don't use if tablets appear abnormal
Frequently Asked Questions
Mesterolone 25 mg FAQ
Answers to common questions about Mesterolone 25 mg, the Mesterolone compound, and its applications.
What is Mesterolone 25 mg used for?
Mesterolone 25 mg contains the oral androgen mesterolone. In clinical medicine, it is indicated for androgen replacement in male hypogonadism and for male infertility associated with oligospermia. In non-medical bodybuilding contexts, it is sometimes referenced for its SHBG binding properties, though such use falls outside approved indications.
How often should Mesterolone 25 mg be taken?
Clinical dosing starts at 3-4 tablets (75-100 mg) daily for several months, followed by maintenance of 2-3 tablets (50-75 mg) daily. In non-medical contexts, mesterolone is commonly referenced at 25-50 mg daily. These non-medical practices are not derived from controlled clinical trials for performance enhancement.
Does Mesterolone 25 mg require PCT?
Early studies suggested mesterolone did not usually suppress gonadotropins or endogenous testosterone production, though a later single-dose study suggests there may be a central suppression effect at doses of 75-100 mg daily. Because of this uncertainty, some non-medical users reference post-cycle therapy after use, though the clinical significance of suppression at lower doses is unclear.
What does Mesterolone do?
Mesterolone acts as an agonist at the androgen receptor and exhibits high binding affinity for sex hormone-binding globulin (SHBG). By binding to SHBG, it may increase the proportion of free, biologically active testosterone in the bloodstream. It does not convert to estrogen, so it does not cause water retention or gynecomastia.
How long does Mesterolone take to work?
Mesterolone is rapidly absorbed after oral ingestion, reaching peak serum levels at approximately 1.6 hours, with a terminal half-life of 12-13 hours. Clinical response in hypogonadism typically requires several months of treatment, as indicated by the recommended initial dosing duration of "several months" before maintenance therapy.
Is Mesterolone the best androgen?
There is no universally established "best" androgen, and mesterolone has not been validated in controlled trials for performance outcomes. Its clinical role is specific to hypogonadism and certain fertility contexts. Its strong androgenic and weak anabolic properties make it unsuitable for significant muscle mass enhancement.
What is the difference between Mesterolone and Oxanabol?
Mesterolone and Oxanabol (oxandrolone) have different activity profiles. Mesterolone is primarily androgenic with weak anabolic activity, while oxandrolone is primarily anabolic with milder androgenic effects. They are used for different purposes in clinical and non-medical contexts.
What is the difference between Mesterolone and Methanabol?
Mesterolone and Methanabol (methandienone) have different characteristics. Mesterolone is a DHT derivative with strong androgenic and weak anabolic activity, while methandienone is a more strongly anabolic oral that aromatizes. Mesterolone does not cause estrogenic side effects.
Is 25 mg of Mesterolone a lot?
Mesterolone 25 mg is labeled at 25 mg of mesterolone per tablet. Clinical starting doses are 3-4 tablets (75-100 mg) daily, so a single 25 mg tablet represents a fraction of the initial clinical dose. In non-medical contexts, 25-50 mg daily is commonly referenced.
What strength is Mesterolone 25 mg?
Mesterolone 25 mg is labeled at 25 mg of mesterolone per tablet. It is supplied as oral tablets in packs of 50 tablets manufactured by British Dragon.
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Package
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Selective Estrogen Receptor Modulator (SERM)
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Strength
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Package
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Form
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Drug Class
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Estimated Half-Life
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